Inclusion Criteria And Exclusion Criteria
Patients FCs were eligible if they met the following criteria:
patients were pathologically diagnosed with cancer and had underwent medical treatments for one or more cycles
FCs were at least 18 years of age
they could understand and fill in the questionnaires truly and correctly
they took care of patients at home and/or in the hospital
FCs voluntarily participated in this study and provided informed written consent.
Patients FCs were not suitable for this study for the following reasons:
FCs had psychiatric conditions or intellectual difficulties.
Compressed Intermittent Theta Burst Stimulation
Sorry, in progress, not accepting new patients
In this proposal the investigators will use an accelerated TMS protocol that concentrates the magnetic stimulation that would usually occur over 6 weeks into 10 treatment sessions per days, for 5 consecutive days in patient with treatment-refractory depression. This protocol will build on a previously published study demonstrating clinical efficacy of intermittent theta-burst stimulation on left dorsolateral prefrontal cortex in a treatment refractory population.
La Jolla, California
Lessons Learned From Clinical Trials Investigating Minor Depressive Disorder
Another concern highlighted by investigations of minor depression is the lack of objective measures of either functional or quality of life impairment. This problem is also true for most studies of most psychiatric disorders. Thus, inspite of the fact that the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition requires functional impairment or quality of life impairment to be present in order for a diagnosis of the syndrome to be made, there have been few efforts to establish some type of criteria for quality of life or functional impairment with these disorders.21 It has been shown in primary care studies that many people who seem to meet criteria for psychiatric syndromes have spontaneous remissions when followed longitudinally. This may well reflect the inclusion of individuals who, because of life stress, have a particular series of signs and symptoms, but in actual fact do not have the pathology associated with a lifelong syndrome. As would be expected, the result of not paying attention to these challenges when designing clinical trials is that the trials tend to be uninformative, if not misleading.
Don’t Miss: How Can I Deal With My Depression
Depression Affects About 10% Of Adults In The United States
Lets break this number down. Thats more than 26 million people who have suffered from depression in the past year, probably not including those who have never been diagnosed or reached out for help. The lifetime prevalence of depression is even higherbetween 15 and 20%.
Depression is one of the most common mental disorders in the United States and can happen to anyoneno matter your age, gender, race/ethnicity, or social background. It is treatable with therapy/counseling and medication.
Neural Mechanisms Of Meditation Training In Healthy And Depressed Adolescents: An Mri Connectome Study
Sorry, in progress, not accepting new patients
The primary objective will be to study changes in putamen structural connectivity in healthy teens with meditation training. Hypothesis: Putamen structural node strength will increase in the training group compared to controls. R61 Go/No-Go Criteria. Detect an effect size in changes of the primary mechanistic outcome by the described meditation training in 100 healthy adolescents that are 14-18 years old and retain at least 80% of randomized participants for primary outcome measurement at the end of the study regardless of adherence to the intervention. The secondary objective will be to study changes in emotional problems in healthy teens with meditation training. Hypothesis: There will be a significant decrease in emotional problems measured with the Strengths and Difficulties Questionnaire in the training group compared to controls. Design and Outcomes: The current research study design will utilize an individually randomized group treatment, open-label, waitlist-controlled clinical trial to test the efficacy and safety of the investigator’s innovative mindfulness meditation intervention on the primary outcome and secondary outcome in healthy adolescents between the ages of 14 to 18 years old.
San Francisco, California
Also Check: Ways To Stop Feeling Depressed
Other Health Conditions Can Cause The Same Symptoms As Depression
- You may have a health condition causing your depression.
- Some people with hypothyroidism experience symptoms of depression along with other symptoms like fatigue, constipation, weight gain, and joint pain.
- Research suggests that almost 15 percent of people with COPD experience depression as well.
- Depression often develops in people who suffer strokes or heart attacks.
- People with cancer are at least twice as likely to develop depression than the general population.
Healthcare Providers As Trusted Messengers To Increase Receipt Of Tax Credits Among Low
Sorry, not yet accepting patients
The purpose of this study is to pilot test the feasibility, acceptability, and preliminary efficacy of healthcare provider referrals to a tax filing app within parent-child health programs to test whether such referrals can increase receipt of tax credits among low-income parents. The study will use a single-group, pre/post test design with a sample of approximately 100 women who have a child under 6 years of age. Participants will be recruited from parental-child health programs and clinics in Los Angeles and will complete surveys at baseline, immediately after tax filing season, and six months after tax filing season to assess 1) frequency of tax filing after referral , 2) the acceptability of the tax filing app from the perspective of users , and 3) pre/posttest changes to parent and child health, child development, and healthcare utilization measures for users .
Recommended Reading: Take Control Of Your Depression
Signs & Symptoms Of Depression
Understanding the Signs and Symptoms of Depression
The everyday occurrences of life can leave everyone feeling sad on occasion. From the breakup of a close relationship to career disappointments, it is natural to experience loneliness and related feelings of sadness. However, when the symptoms of depression begin to impact your quality of life, you need to take action.Adults and teens exhibit somewhat different symptoms of depression, with some overlap in signs. Clinical depression can result in physical symptoms and behavioral concerns.
What Are the Main Signs of Depression in Adults?
If you have ongoing difficulties concentrating and remembering details, it could be due to chronic depression. Other mental symptoms of depression include loss of interest in previously pleasurable activities, including sex.
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Erratic sleeping patterns including staying up all night
How Can Insight Clinical Trials Help
If you are feeling depressed you are not alone.
Your first visit to Insight Clinical Trials will consist of a free mental health evaluation. You do not have to have previously been diagnosed with depression.
All of the assessments done throughout the study are free of cost and study medication is also provided at no cost. If you are interested in learning more about the depression studies then complete the web form or give us a call to schedule an appointment.We currently have several different opportunities for research treatments.
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We are looking for study candidates that are treatment-naive
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We are seeking those that have previously taken antidepressants before, but are not currently
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We are also enrolling patients taking an approved antidepressant medication without the desired results
Also Check: Signs You Need Depression Medication
Current Depression Clinical Trials
Clinical trials are a great way to help further research regarding depression, and also to get access to care from experts in the field.
Depression clinical trials are mostly carried out to determine the safety and efficacy of new medications and procedures, and they are led by a research team. A patient can obtain life-changing treatments through a clinical trial however, it is important to note that if the patient wishes to leave the trial for any reason, they may do so at any point during the research.
- on December 22, 2022 at 5:00 pm
Condition: DepressionIntervention: Behavioral: Personalized Behavioral InterventionSponsor: University of California, San DiegoRecruiting
- on December 20, 2022 at 5:00 pm
Conditions: Major Depressive Disorder MDD Cognitive ImpairmentInterventions: Drug: Xanamem Drug: PlaceboSponsors: Actinogen Medical AXIOM Real Time MetricsRecruiting
- on December 19, 2022 at 5:00 pm
Conditions: ECT DepressionInterventions: Drug: Methohexital Drug: KetofolSponsor: Medical University of ViennaRecruiting
How Is Depression Treated
Patients with depression usually have a positive response to treatment. However, it is important to remember that not all patients react in the same way to the same treatments. Therefore, it is possible that you will need to try different alternatives before finding a treatment that works for you. Depression is usually treated with a combination of medications and therapy.
Antidepressants are meant to regulate the brain chemistry in order to relieve depression. Although some improvement might be seen after a couple of weeks into the treatment, their full effect isnt usually apparent until 1-3 months taking the medication, and they are usually prescribed for at least 6 months.
Antidepressants include:
- Selective serotonin reuptake inhibitors : citalopram, escitalopram, fluoxetine, sertraline, paroxetine, vortioxetine amongst others.
- Serotonin/norepinephrine reuptake inhibitors : venlafaxine, duloxetine, levomilnacipran, levomilnacipram , amongst others.
- Serotonin-Dopamine Activity Modulators : brexpiprazole, aripiprazole.
- Tricyclic antidepressants : amitriptyline, clomipramine, doxepin, nortriptyline, amongst others.
- Monoamine oxidase inhibitors : isocarboxazid, phenelzine, tranylcypromine, and selegiline amongst others.
- Atypical antidepressants: mirtazapine, bupropion, trazodone, amongst others.
Use of Psychotherapy in Depression Treatment
Read Also: How To Be Positive With Depression
Near Infrared Spectroscopy For Assessment Of Depression
open to eligible people ages 18 years and up
Develop a NIRSIT testing protocol that can be administered in the diagnostic setting and reliably distinguishes the symptoms and severity of depression, with the help of repeated measure comparison of patients being treated for Major Depressive Disorder with control, non-depressed subjects.
San Francisco, California
You Can Feel Depressed Without Having The Typical Symptoms Of Depression
You can feel depressed without having the typical symptoms of depression.
Many people think that depression involves constant sadness, but in fact, its a bit more complicated than that. While some people may only experience depression as a sense of sadness, many people also have other symptoms, such as physical pain and fatigue. Depression can present itself differently depending on the individual. For example:
Read Also: Does Manic Depression Run In Families
A Study Of Esketamine Nasal Spray Administered As Monotherapy In Adult Participants With Treatment
open to eligible people ages 18 years and up
The purpose of this study is to evaluate the efficacy of each individual dose of esketamine nasal spray, 56 milligram and 84 mg, compared with placebo nasal spray in improving depressive symptoms in participants with treatment resistant depression , as assessed by the change from baseline in the Montgomery-Asberg Depression Rating Scale total score from Day 1 to the end of the 4 week double-blind treatment phase .
San Francisco, California
A Study Of Aticaprant 10 Milligrams As Adjunctive Therapy In Adult Participants With Mdd With Moderate
Sorry, not currently recruiting here
The purpose of this study is to evaluate the efficacy of aticaprant compared with placebo as adjunctive therapy to an antidepressant in improving depressive symptoms in adult participants with major depressive disorder with moderate to severe anhedonia who have had an inadequate response to current antidepressant therapy with a selective serotonin reuptake inhibitor or serotonin-norepinephrine reuptake inhibitor .
San Diego, California
Also Check: Postpartum Depression Starting At 3 Months
Meditation Accelerated Brain Stimulation For Depression
open to eligible people ages 18 years and up
Repetitive Transcranial magnetic stimulation is an FDA-approved treatment for depression that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex brain region. The ultimate goal of this treatment is to increase excitability and long-term plasticity in DLPFC, a brain region shown to be hypo-active in depression. Unfortunately, rTMS only has low to moderate efficacy remission rates for patients range from ~15-30% in large randomized controlled trials. The focus of this research is to develop a next-generation rTMS protocol that is guided by the basic principles underlying brain plasticity, in order to improve the efficacy of rTMS for the treatment of depression. Specifically, in this study the investigators will test rTMS paired with a depression-relevant cognitive state of internal attention.
San Diego, California
Affect Treatment For Depression And Anxiety
open to eligible people ages 18-65
The purpose of this study is to evaluate the efficacy and mediators of change in Positive Affect Treatment, a psychotherapy specifically aimed at enhancing reward sensitivity in individuals with low positive affect in the context of depression or anxiety. Target enrollment is 100 male and female participants with low positive affect and depression or anxiety and impaired functioning, between the ages of 18 and 65 years, who will be randomized to either Positive Affect Treatment or Negative Affect Treatment . Participants will complete laboratory tests, psychiatric assessments, and self-report questionnaires as part of the study. The total length of participation is around 5 months.
Los Angeles, California
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Mindfulness Meditation Neuroimaging Study For Undergraduates
open to all eligible people
This study is designed to test the effectiveness of mindfulness meditation intervention classes on psychosocial health outcomes. Additionally, the investigators would like to examine changes in the brain that might occur following the mindfulness meditation intervention. The investigators are particularly interested in changes in brain activity that are correlated with changes in inflammation-related markers in the blood. The nervous system and immune system are closely connected, and both are influenced by mindfulness. However, it is unclear whether changes in neural activity are linked with changes in inflammation. A compelling feature of mindfulness interventions is their potential for reducing inflammatory activity however, this has not been examined in college students. In addition to measuring psychosocial outcomes, the investigators will employ sophisticated, vertically-integrated measures of inflammatory biology that allow the study team to probe intervention effects on circulating markers of inflammation. Thus, the investigators intend to recruit 60 undergraduate students and will randomize them into either a 6-week standardized mindfulness intervention or to a wait-list control group. Participants will complete brain scans, provide blood samples for immune analysis, and complete questionnaires at pre- and post-intervention assessments
Los Angeles, California
Bipolar Efficacy Biomarkers For Rtms
open to eligible people ages 18-70
The research study is being conducted to test whether using high dose spaced theta-burst rTMS produces a significant reduction in depressive symptoms compared with sham. This project will recruit patients aged 18-70 with symptoms of bipolar depression who have failed after at least two prior treatments. The null hypothesis is that there will be no difference in reductions in depressive symptoms by the end of a five-day treatment period. The alternative hypothesis is that, compared with sham, active TMS will result in a greater reduction in depressive symptoms by the end of the treatment period. To facilitate the development of rTMS protocols there is a need for biomarkers that are sensitive to BPD symptom severity and clinical improvement. Previously in our lab, investigators developed biomarkers suitable for depression trials, and these biomarkers are very likely to show sensitivity to BPD, since they are associated with brain regions and functions associated with BPD. As a secondary aim, the investigators will try to identify biomarkers in cortical region associated with BPD, and formulate a statistical model that may be able to predict BPD remission after the treatment. this study will lead to development of new brain stimulation treatment protocols and biomarkers, will aid in treatment selection, and eventually lead to better clinical outcome for patients suffering from BPD.
San Diego, California
Recommended Reading: Does Sleeping All Day Cause Depression
Attachment And Biobehavioral Catch
open to eligible females ages 2 years and up
Maternal depression influences the development of children’s behavior problems and vice versa however most interventions singularly address maternal depression or children’s behavior problems rather than both. This project assesses the efficacy of an intervention that treats both mothers and children in an integrated manner. Effects are expected to disrupt the reciprocal relations that perpetuate maternal and child mental health problems over time.
San Francisco, California
Pain And Major Depressive Disorder
Sorry, not yet accepting patients
This study will examine the effects of brain stimulation on pain symptoms associated with Major depressive disorder. This study will enroll 69 Subjects. Study subjects will be asked to complete surveys about their mood and well-being, 2 blood draws, 2 MRIs, 3 electroencephalograms, and receive 30 treatments of blinded transcranial magnetic stimulation. There is no control group as all subjects will receive some form of active treatment. Subjects are required to participate in 30-33 study visits and volunteer 40 hours of their time. Compensation for this study is $150 for completing all study activities.
Los Angeles, California
Also Check: Signs Of Bipolar Manic Depression
Vistagen Announces Completion Of Last Patient Last Visit In Phase 2 Clinical Trial Of Ph94b For The Treatment Of Adjustment Disorder With Anxiety
Topline results of the exploratory Phase 2 clinical study anticipated in Q1 2023
SOUTH SAN FRANCISCO, Calif., January 10, 2023—-Vistagen , a late clinical-stage biopharmaceutical company aiming to transform the treatment landscape for individuals living with anxiety, depression, and other central nervous system disorders, today announced that the last patient has completed the study protocol in its Phase 2 clinical trial of PH94B for the treatment of adults experiencing adjustment disorder with anxiety .
The exploratory Phase 2 clinical trial is a U.S. multi-center, randomized, double-blind, placebo-controlled study intended to evaluate efficacy, safety and tolerability of PH94B administered four times per day over four weeks for the treatment adjustment disorder with anxiety symptoms in adults. The primary endpoint is the change from baseline in anxiety level as measured by the Hamilton Anxiety Rating Scale at the end of Week 4 of treatment with PH94B or placebo. Dr. Michael Liebowitz, a former Columbia University psychiatrist, founder of the Anxiety Disorders Clinic at the New York State Psychiatric Institute, and currently director of the Medical Research Network in New York City, is serving as Principal Investigator of the trial. Topline results are anticipated at the end of Q1 2023.
About PH94B
About Adjustment Disorder
About Vistagen
Forward Looking Statements
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