Drugs Types That May Cause Depression
The following kinds of medications are among those that may lead to depression:
1. Beta-blockers and ACE inhibitors : metoprolol, atenolol, enalapril, and quinapril.
2. Antidepressants: sertraline , citalopram , bupropion , and amitriptyline.
3. Anti-anxiety drugs: alprazolam , clonazepam , diazepam , and lorazepam , as well as the sedative zolpidem .
4. Opioids: hydrocodone combination meds and tramadol .
5. Corticosteroids: prednisone and others.
6. Over-the-counter proton pump inhibitors: omeprazole and esomeprazole , as well as the antacids ranitidine and famotidine .
7. Allergy and asthma medications: over-the-counter cetirizine and the prescription drug montelukast .
8. Anticonvulsants: gabapentin and topiramate .
9. Hormones: estradiol and finasteride .
Eliquis And Other Medications
Below are medications that can interact with Eliquis. This section doesnt contain all drugs that may interact with Eliquis.
Before taking Eliquis, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
Eliquis and antiplatelets, including aspirin
Taking Eliquis with an antiplatelet drug can raise your risk for bleeding. You shouldnt take Eliquis with an antiplatelet drug unless your doctor recommends it. Antiplatelets are drugs that help prevent blood clots. Eliquis also helps prevent blood clots, but it works differently than antiplatelets.
Eliquis works by attaching to an activated blood clotting factor, called factor Xa. Eliquis stops this clotting factor from working, which makes your blood less able to form clots. Antiplatelets, on the other hand, interfere with the binding of platelets.
Examples of antiplatelet drugs include:
If youre taking an antiplatelet drug, ask your doctor if you should continue taking it when you start Eliquis. If your doctor recommends taking Eliquis with an antiplatelet, see them right away if you have any bleeding problems. To learn more, see the Eliquis side effects section above.
Eliquis and other anticoagulants
Will I Need To Use This Drug Long Term
You might, but it depends on why youre taking Xarelto. The length of time Xarelto treatment is used is based on why youre taking the drug. Typical treatment lengths are as follows:
- If youre taking Xarelto after having a knee replacement, youll take the drug for 12 days after your surgery.
- If youre taking Xarelto after having a hip replacement, youll take the drug for 35 days after your surgery.
- If youre taking Xarelto because you were admitted to a hospital for an acute illness, youll take the drug for 31 to 39 days.
- If youre taking Xarelto to treat a deep vein thrombosis or pulmonary embolism , youll take the drug for 6 to 12 months.
However, when its prescribed to prevent blood clots or their complications, Xarelto is meant to be used as a long-term treatment. If you and your doctor determine that Xarelto is safe and effective for you, youll likely take it long term for these purposes.
If you have coronary artery disease or peripheral artery disease , youll take Xarelto with aspirin.
With CAD, you have narrowed arteries in your heart. With PAD, you have narrowed arteries in your legs. Both of these conditions increase your risk of having blood clots that can cause a heart attack or stroke.
Using a combination of Xarelto and aspirin is more effective for preventing heart attack and stroke in people with CAD or PAD than using aspirin alone.
The recommended dosage of aspirin for this use is 75 mg to 100 mg taken once a day.
You May Like: What Medication Can Help Depression
How To Tell If The Bleeding Is An Emergency
When youâre taking a blood thinner, says Gomes, you may bruise more easily and may also notice bleeding around your gums after brushing your teeth. In most cases, bleeding caused by blood thinners is not serious, according to the NBCA. If you get a minor cut while working in the yard or the kitchen, the bleeding might last longer than usual. You could also experience frequent nosebleeds that last for several minutes. Though frustrating and inconvenient, these occurrences arenât life-threatening.
However, blood thinners can cause dangerous bleeding that requires immediate medical attention, says Gomes. Major bleeding complications include internal bleeding in the stomach, bowel, or brain, he says. âThis could be life-threatening, he adds. Intracranial hemorrhage is the most feared complication. And, Haut notes, the damage caused by bleeding in the brain may be irreversible.
So, in addition totaking steps to prevent bleeding, itâs also important to recognize the warning signs of this potentially serious side effect:
- Excessive menstrual bleeding
- Blood in the urine or bowel movements
Treatment Of Depression In Patients On Anticoagulation Therapy: Antidepressant
Shari N. Allen, PharmD, BCPPAssistant Professor of Pharmacy PracticePhiladelphia College of Osteopathic Medicine School of PharmacySuwanee, Georgia
Assistant Professor of Pharmacy PracticePhiladelphia College of Osteopathic Medicine School of PharmacySuwanee, Georgia
Lilys Pharmacy of Johns CreekJohns Creek, Georgia
Lilys Pharmacy of Johns CreekJohns Creek, Georgia
US Pharm. 2013 38:23-26.
ABSTRACT: When used as monotherapy, warfarin is associated with an increased risk of bleeding. When warfarin is used concomitantly with other drugs that may also increase the risk of bleeding or affect the concentration of warfarin, the bleeding risk may be further increased. The combined use of warfarin and antidepressants, particularly the selective serotonin reuptake inhibitors, may lead to drug-drug interactions via pharmacodynamic and pharmacokinetic mechanisms. Limited data exist concerning the potential for drug-drug interactions between warfarin and antidepressants. When it is necessary to use both warfarin and an antidepressant, it is recommended to select an agent with minimal effect on the CYP450 system and a lower degree of inhibition of serotonin reuptake, as well as to increase the frequency of monitoring of the international normalized ratio and signs and symptoms of bleeding.
You May Like: Being Manic And Depressed At The Same Time
What Should I Watch Out For If I Use St John’s Wort
- Increased sensitivity to the sun, especially if you are fair-skinned and taking large doses
- Increase in blood pressure
Do not take St. John’s wort during pregnancy or while you are breastfeeding.
St. Johns wort has been associated with very serious and potentially dangerous interactions with many common drugs. St. Johns wort can weaken how well other drugs work, including antidepressants, birth control pills, cyclosporine , digoxin , HIV drugs, cancer medications, and blood thinners such as Coumadin.
Taking St. Johns wort with antidepressants can cause a dangerous increase in levels of serotonin, a hormone that affects mood. This condition is known as serotonin syndrome.
Always tell your doctor or pharmacist if you are taking St. John’s wort or any other herbal product. St. Johns wort should not be used in place of standard antidepressants.
Ways To Prevent Bleeding Risks
If youre taking blood thinners, following these steps can reduce your risk for potentially serious bleeding:
1. Follow your treatment plan to a T. Be sure youâre taking your medication exactly as directed by your doctor. If you dont take enough of the blood thinner, it might not be able to prevent a clot. But if you take too much, it can increase your risk for bleeding even further, according to the American Heart Association . Typically, the AHA recommends that people on blood thinners should have their blood monitored on a monthly basis.
2. Avoid taking drugs that can increase your risk of heavy bleeding. That includes non-steroidal anti-inflammatory drugs like Advil and Motrin , and Aleve , says , associate staff member in the section of vascular medicine at the Robert and Suzanne Tomsich Department of Cardiovascular Medicine at the Sydell and Arnold Miller Family Heart & Vascular Institute of the Cleveland Clinic in Ohio. Some supplements also can increase your risk of bleeding, says Dr. Gomes. St. Johns wort is one theres also some concern that high doses of omega-3 supplements can make blood thinners more potent, according to the Cleveland Clinic. If you havenât done so already, tell your doctor about every dietary supplement you are currently using and consult with him or her before taking any new ones even if those products are labeled as safe or all natural.
RELATED: The Best Diet to Prevent a Stroke
Also Check: Can Depression Make You Feel Emotionally Numb
How To Stop Taking Xarelto
You should keep taking Xarelto for as long as your doctor recommends that you do so.
Dont stop taking Xarelto without first discussing it with your doctor. Stopping Xarelto increases your risk of having a blood clot. If youre taking Xarelto because you have heart disease or disease in your arteries, stopping the drug increases your risk of having a stroke or heart attack.
If you need to stop taking Xarelto temporarily because youre going to have a surgical, medical, or dental procedure, you should usually stop taking it at least 24 hours before the procedure. However, always follow the instructions given by your doctor.
If you need to stop taking Xarelto for any other reason, talk with your doctor about when to stop taking it. Your doctor will usually prescribe a different anticoagulant drug to help prevent blood clots while youre not taking Xarelto.
Read Also: Shortness Of Breath Fatigue No Energy
Proton Pump Inhibitors And H2 Blockers
Why they’re prescribed: Doctors typically prescribe these medications, which suppress the secretion of gastric acid, to treat gastroesophageal reflux disease .
How they can cause depression: While these drugs are known to cause depression, scientists don’t yet understand why they do. When any major body process is blocked, however, the body often rebels in an intense effort to fight back. Consequently, it’s altogether likely that changing the pH of the stomach could bring on changes to the central nervous system and the brain.
Alternatives: Know which foods trigger your acid reflux and avoid them, especially in the hours before bedtime. A non-calcium-carbonate-based antacid, such as Mylanta, may also help. Many of my patients have reported relief from the home remedy of apple cider vinegar and honey , though I know of no scientific research that confirms the effectiveness of this approach.
Don’t Miss: What To Do When You Are So Depressed
How Should This Medicine Be Used
Venlafaxine comes as a tablet or extended-release capsule to take by mouth. The tablet is usually taken two or three times a day with food. The extended-release capsule is usually taken once daily in the morning or evening with food. Take venlafaxine at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take venlafaxine exactly as directed. Do not take more or less of it or take it more often or for a longer period of time than prescribed by your doctor.
Swallow the extended-release capsule whole do not split, chew, or crush it, or place it in water. If you cannot swallow the extended-release capsule, you may carefully open the capsule and sprinkle the entire contents on a spoonful of applesauce. Swallow this mixture immediately after preparation and then drink a glass of water to make sure that you have swallowed all of the medication.
Your doctor will probably start you on a low dose of venlafaxine and gradually increase your dose, not more often than once every 4 to 7 days. Tell your doctor how you are feeling during your treatment so that your doctor can adjust your dose properly.
The Nation: Side Effects Your Zoloft Might Prevent A Heart Attack
-
Send any friend a story
As a subscriber, you have 10 gift articles to give each month. Anyone can read what you share.
Give this articleGive this articleGive this article
PATIENTS are beginning to treat depression with respect. Whether their doctors are ready to do so is less clear.
A study in the current issue of The Journal of the American Medical Association finds that almost six in 10 Americans who suffer depression seek treatment in a given year. A decade ago, the figure was one in three.
But the researchers found that only about 40 percent of patients received what standard guidelines consider ”minimally adequate medical treatment.” Those criteria call for a month of antidepressants monitored in four office visits or eight half-hour counseling sessions.
There is a long tradition in general medicine of ignoring or undertreating depression. But a second article in JAMA suggested reasons that the pattern may change. That report described the largest study of psychotherapy ever conducted, sponsored by the National Heart, Lung and Blood Institute.
The study is a response to evidence, developed over the past decade, that depression, like diabetes and hypertension, is a risk to the heart. By middle age, studies show, depression triples or quadruples the risk of cardiac death. The most acute danger comes in the wake of heart attacks. After a first attack, depression raises the risk of recurrence dramatically — between two- and fourfold.
Recommended Reading: Social Security For Anxiety And Depression
Blood Pressure And The Heart
Theres a reason why your blood pressure is taken every time you visit a doctors office or hospital, regardless of the complaint that brought you there. High blood pressure is rightly known as the silent killer. It often carries no symptoms or warning signs but can drastically increase your risk of having a heart attack or stroke. The higher the number, the harder your heart is having to work to pump blood around your body and the more likely it is that damage is being done to the heart muscle. Since all parts of your body rely on circulation, though, its not just your heart that high blood pressure can impact. If blood doesnt flow easily, it can harm your arteries as well as vital organs such as the kidneys, eyes, and brain.
High blood pressure has been shown to damage the tiny blood vessels in the parts of your brain responsible for cognition and memory, greatly increasing your risk of developing Alzheimers disease or another dementia. Being diagnosed with cardiovascular disease can also take an emotional toll, affecting your outlook and making you more susceptible to anxiety and depression. And just as blood pressure may have an impact your mood, the reverse can also be true:
Can I Take Eliquis Once A Day
No, Eliquis needs to be taken twice a day. This helps keep a steady level of the drug in your blood.
Certain other blood thinners can be taken once a day. These include warfarin , rivaroxaban and enoxaparin .
If youre interested in a blood thinner that you take only once a day, talk with your doctor.
Read Also: Is Depression Medication Right For Me
Eliquis And Food Interactions
Grapefruit: The only food that seems to have a negative interaction with Eliquis is grapefruit. Studies show that if you consume grapefruit or grapefruit juice while taking Eliquis, you have a higher chance of experiencing bruising or bleeding.
Lack of appetite: One significant correlation between Eliquis and food is how it can drastically reduce your appetite. The lack of hunger is usually a result of an upset stomach, diarrhea, or bloating. If you notice a sudden lack of appetite or weight loss after taking Eliquis, consult with your doctor for more information.
Also Check: Reasons For Fatigue In Females
Xarelto For Preventing Vte In People Who Are Ill
Xarelto is FDA-approved to prevent venous thromboembolism in people who are admitted to a hospital with an acute medical illness. The drug is approved for this use in people who have an increased risk of blood clots, but who dont have a high risk of bleeding.
A VTE is a blood clot that forms in one of your veins . VTEs can travel throughout your body, including to your lungs. Youre at an increased risk of having a VTE if youre on bedrest or you cant move around very much.
Other risk factors for VTE include:
- having had a blood clot in the past
- a history of cancer
- a history of heart failure
- being 75 years of age or older
Xarelto is an anticoagulant . Its taken to prevent blood clots during your hospital stay. Youll also take it for a while after youre discharged from the hospital.
Effectiveness for preventing VTE in people who are ill
One clinical study compared treatment with Xarelto to treatment with enoxaparin for preventing VTE in people who were admitted to a hospital.
In this study, Xarelto was more effective than enoxaparin followed by a placebo in preventing blood clots in people admitted to the hospital.
For both Xarelto and enoxaparin, treatment was started in the hospital and continued after people were discharged from the hospital. One group of people took Xarelto for 31 to 39 days. A second group took enoxaparin for 6 to 14 days while they were in the hospital. This second group of people were then given a placebo to take after theyd been discharged.
Read Also: Natural Remedies For Stress And Depression
Can You Ever Get Off Eliquis
Eliquis is designed to reduce the risk of stroke by preventing blood clots. If you suddenly stop taking it, you are at a higher risk of experiencing a stroke or blood clots. Therefore, you should always consult with your doctor before you stop taking Eliquis. Your doctor will typically prescribe another medication to prevent blood clots.
Some situations, like an upcoming surgery or dental procedure, might require you to stop taking Eliquis. In that case, your doctor can determine what the best temporary solution is.
Eliquis For Preventing Dvt That Could Lead To Pe After A Hip Or Knee Replacement
Eliquis is FDA-approved to prevent DVT that could lead to PE in people whove had hip or knee replacement surgery. These surgeries raise your risk for DVT. This is because the process of replacing your hip or knee can damage blood vessels around the joint, which can lead to DVT.
In addition, after the surgery youll be less mobile for a while. This means your blood will flow more slowly and could clot more easily. These issues can lead to a blood clot forming in a vein in your leg. If the clot dislodges, it can travel through your bloodstream to your lungs and lead to a PE.
Eliquis helps prevent blood clots, so it lowers your risk for having a DVT or PE after a hip or knee replacement.
Effectiveness for preventing DVT and PE after hip or knee replacement
Eliquis was found to be effective for preventing DVTs and PEs following hip or knee replacement surgeries in three clinical studies. In these studies, Eliquis was compared with enoxaparin . Enoxaparin is an effective, widely used anticoagulant thats given by injection.
One study looked at people who took either 30 mg of Eliquis or enoxaparin for an average of 35 days following hip replacement surgery. A DVT or PE, or death from any cause, occurred in:
- 1.39% of people who took Eliquis
- 3.86% of people who took enoxaparin
Two studies looked at people who took Eliquis or enoxaparin for an average of 12 days following knee replacement surgery. PE occurred in:
Don’t Miss: Is Depression A Mental Issue